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M94A2995.TXT
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1994-10-25
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Document 2995
DOCN M94A2995
TI AIDS-related primary central system lymphoma treated with radiotherapy:
over a decade of clinical experience at UCSF.
DT 9412
AU Ling C; Coleman L; Roach M; Wara W
SO Int Conf AIDS. 1994 Aug 7-12;10(1):178 (abstract no. PB0137). Unique
Identifier : AIDSLINE ICA10/94369580
AB OBJECTIVES: To determine the length of survival of patients with
AIDS-related primary central nervous system lymphoma (PCNSL) after
treatment with radiotherapy, and to determine whether length of survival
(LOS) correlated with dose of radiotherapy, pre-treatment Karnofsky
performance status (KPS), risk factors, age, CD4 counts, length of time
since seroconversion, clinical response, radiological findings,
pathology, chemotherapy or AIDS medications, clinical symptomatology or
presence of other AIDS-related illnesses. METHODS: Using our
diagnosis-based computer retrieval system all patients treated with
radiotherapy for AIDS-related PCNSL between January, 1982 and January,
1994 were identified and their medical records were reviewed. Population
characteristics, risk factors and LOS were analyzed. Statistical
methodology included the Cox proportional hazards model and Kaplan-Meler
survival curves. RESULTS: 57 patients were identified as having
AIDS-related PCNSL. Although there was an eightfold increase of cases in
the last six years of this study as compared with the first six years,
this now appears to be levelling off. The average KPS score was 50. The
median LOS was 3 months and did not appear to correlate significantly
with any of the above factors except for KPS score. CONCLUSIONS: The
outcome of AIDS-related PCNSL continues to be dismal despite improved
general medical and supportive care.
DE Brain Neoplasms/MORTALITY/*RADIOTHERAPY *Cranial Irradiation Follow-Up
Studies Human Karnofsky Performance Status Lymphoma,
AIDS-Related/MORTALITY/*RADIOTHERAPY Proportional Hazards Models
Radiotherapy Dosage Survival Rate MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).